从国内外指南推荐,看MET 14号外显子跳跃突变的检测现状
2022-07-16
作为国内指导非小细胞肺癌(NSCLC)诊疗的权威参考,中国临床肿瘤学会(CSCO)NSCLC诊疗指南,既能够用于指引临床诊疗,也反映着肺癌治疗研究的最新发展趋势,广大临床工作者都对一年一度的指南更新高度关注。
CSCO指南的这一更新,不仅结合了MET抑制剂在我国已经可用的最新进展,还与国外指南和共识的推荐基本接轨,凸显出MET 14号外显子跳跃突变这个罕见突变,在NSCLC靶向治疗中地位的不断上升。在指南更新的大背景下,有必要再度了解MET 14号外显子跳跃突变的检测方法和国内外指南推荐现状,从而为患者选择最合适的检测方法,真正做到“精准治疗、检测先行”。
01
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逐步成为“必检基因”
MET 14号外显子跳跃突变检测热度升温
02
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检测MET 14号外显子跳跃突变
在临床实践中该如何进行?
03
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总结
MET 14号外显子跳跃突变已成为NSCLC靶向治疗中又一个炙手可热的“罕见突变”,检测手段和药物治疗都在快速发展,我国患者也已经有药可用,从赛沃替尼等创新药物的治疗中显著获益,CSCO指南更新也顺应这一发展趋势,上调了MET 14号外显子跳跃突变的检测推荐级别,有助于让临床工作者和患者提高检测意识,争取更多靶向治疗的机会。结合患者特点和检测可及性,进一步优化检测策略,也有助于真正落实“精准治疗、检测先行”的理念。
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